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FRIDAY, JULY 15, 2022 (HealthDay News) – Adherence to a healthy lifestyle is associated with a near 50 percent lower risk of developing lethal prostate cancer among men at high risk for the disease, according to a recent study published in European Urology.

Anna Plym, Ph.D., of Brigham and Women’s Hospital in Boston, and colleagues examined whether men with an increased genetic risk for prostate cancer can compensate for their risk for the disease or the progression of the disease by adhering to it. a healthy lifestyle. The analysis included 12,411 genotyped men participating in the Follow-up Study of Health Professionals (1993 to 2019) and the Health Study of Physicians (1983 to 2010).

The researchers found that the point of polygenic risk (PRS) allowed risk stratification not only for general prostate cancer but also for lethal disease, with a four-fold difference between men in the higher quartiles. and lower (hazard ratio, 4.32). Adherence to a healthy lifestyle was associated with a decrease in the rate of lethal prostate cancer (risk ratio, 0.55) for men in the highest PRS quartile compared to having an unhealthy lifestyle, making a lifetime risk of 1.6 percent among healthy men and 5.3 percent among healthy men. the sick men. There was no visible association between adherence to a healthy lifestyle and a decreased risk for prostate cancer in general.

“Having a high genetic risk is often seen as something very deterministic, but our findings suggest that it may not be,” Plym said in a statement. “Through lifestyle changes, early screening and early treatment we may be able to deal with high genetic risks.”

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